Also known as: GnRH, Factrel, Lutrepulse
Synthetic GnRH, used by some TRT clinics to keep the testes working.
Educational reference, not medical advice. Many compounds here are not approved, and products sold as research chemicals are not checked for purity. Plan any use with a licensed clinician.
How it works
Stimulates the pituitary to release LH and FSH. Pulsed dosing stimulates; constant exposure suppresses.
Evidence by goal
| Goal | Grade | What the grade means |
|---|---|---|
| Testosterone & fertility | C | Limited human data, case series or practitioner reports |
At a glance
- Route
- Subcutaneous
- Half-life
- About 10 to 40 minutes
Reported dosing
Clinic use on TRT: 100 to 200 mcg SC 2 to 3 times weekly. Fertility: pump delivering pulses every 90 minutes.
Timing: Morning.
Cycle: Ongoing alongside TRT.
From approved labels where they exist, otherwise from published trials and practitioner reports.
Side effects
- Headache, flushing
- Injection-site reactions
Who should avoid it
- Hormone-sensitive cancers
Often combined with
With TRT. hCG has stronger evidence for preserving testicular size and sperm on TRT.
Key findings
Pulsatile pump therapy works well for hypothalamic infertility. Evidence for twice-weekly injections on TRT is weak because of the very short half-life.
Where it is legal (Oct 2026)
| US | Compounded prescription |
|---|---|
| Canada | Not approved |
| Mexico | Verify locally |
| EU | Prescription |
EU: prescription in some states (diagnostic or veterinary use).
Sources
Open Gonadorelin in the Peptide Guide Compare all peptides by goal
Last reviewed November 2026. Regulatory status reflects the US unless noted and changes often.